A plausible mechanism of muscle stabilization in stall conditions

We address the well-known limitation of Huxley and Simmons 1971 (HS) model. It is a statement that at physiological value stiffness in actomyosin complex, distribution myosin motors becomes microscopically uniform (all are either pre- or post-power stroke conformation) after an infinitesimal displacement from stall (isometric contractions) conditions. Such behavior fiber level would generate negative slope $T_2-\delta$ relationship (in nomenclature HS paper), not observed experimentally. This means inhomogeneity macroscopic sarcomere configuration, which also observed. To this controversial prediction theory, we explore possibility curve is, fact, positive due to interaction between neighboring cross-bridges. show such can potentially destabilize configurations pre all post) by making non-uniform energetically preferable. argue that, despite presence other factors, principle ensure microscopic cross-bridge configurations, implied important player muscle mechanics.